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pentobarbital will lessen the level or effect of almotriptan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital will lessen the level or outcome of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Utilization of naloxegol with powerful CYP3A4 inducers is not proposedBreast